Neurology Main > Neuroimmunology & Multiple Sclerosis
ln

FAQ
Glossary
Research
- Clinical Trials
Treatment
- Cyclophosphamide (Cytoxan)
- First Line Disease Modifying Therapies
- Intravenous Immunoglobulin (IVIG)
- Methotrexate
- Mitoxantrone (Novantrone)
- Natalizumab (Tysabri)
- Rituximab (Rituxan)
- Solu-Medrol

Appointments and Referrals

Faculty
- Jaime Imitola, MD
- D. Joanne Lynn, MD
- Michael Racke, MD
Infusion Nurses
- Cynthia Hunter, RN
- Nancy, Ficco, RN
Research Staff
- Misty Regula
- Stephanie Scarberry, RN

Contact us at 614.293.4969

Dr. ImitolaJaime Imitola, MD
Assistant Professor of Neurology and Neuroscience

OSU Appointment: 2013

Research Background:

The molecular basis for the responses of neural stem cells (NSCs) to injury and chronic neuroinflammation are unknown. In mouse models of multiple sclerosis, chronic neuroinflammation have deleterious effects in NSCs (Imitola et al, 2011) by decreasing their self-renewal capacity.

Our goal is to identify and validate genes that mediate the responses of neural stem cells (NSCs) to CNS injury in multiple sclerosis and brain cancer in the so-called injury-induced stem cell niches.

Few candidate genes have been validated for NSCs function in CNS pathology such as the chemokine receptor CXCR4 that mediates the migration of human NSCs to sites of Injury and brain tumors (Imitola et al, 2004). We hope to translate novel molecular targets on NSCs to enhance human CNS repair and regeneration.

Current Research:

1. Inflammation transcriptional control of NSCs and brain cancer stem cell intrinsic properties.
2. Modeling inflammation-induced neurodegeneration and repair with iPSCs

NLM Pubmed publication list for Jaime Imitola, MD (last 10 years)

Peer Reviewed Journal Articles

Imitola J*, Rasmussen S*, et al, Reversible neural stem cell niche dysfunction in a model of multiple sclerosis. Ann Neurol. 2011 May;69(5):878-91. (Co-first) (Cover).

Imitola J, et al Multimodal coherent anti-Stokes Raman scattering microscopy reveals microglia-associated myelin and axonal dysfunction in multiple sclerosis-like lesions in mice. J Biomed Opt. 2011 Feb;16(2):021109.

Starossom SC*, Imitola J*, et al Subventricular zone microglia transcriptional networks. Brain Behav Immun. 2011 Jul;25(5):991-9 (Co-first)

Wang Y, Imitola J, et al Paradoxycal dysregulation of the neural stem cell pathway sonic hedgehog-Gli1 in autoimmune encephalomyelitis and multiple sclerosis. Ann Neurol. 2008 Oct; 64(4):417-27.

Esposito G, Imitola J, et al Genomic and functional profiling of human Down syndrome neural progenitors implicates S100B and aquaporin 4 in cell injury. Hum Mol Genet. 2008 Feb 1;17(3):440-57.

Rasmussen S, Wang Y, Kivisäkk P, Bronson RT, Meyer M, Imitola J*, Khoury SJ*. Persistent activation of microglia is associated with neuronal dysfunction of callosal projecting pathways and multiple sclerosis-like lesions in relapsing-remitting experimental autoimmune encephalomyelitis. Brain. 2007 Nov;130(Pt 11):2816-29. (Co-correspondent authors).

Imitola J, et al. Directed migration of neural stem cells to sites of CNS injury by the stromal cell-derived factor 1alpha/CXC chemokine receptor 4 pathway. Proc Natl Acad Sci U S A. 2004 Dec 28;101(52):18117-22. (Cited 545 times).

Imitola J, et al Am J. Neural stem/progenitor cells express costimulatory molecules that are differentially regulated by inflammatory and apoptotic stimuli. Am J. Pathol. 2004 May;164(5):1615-25.

Sheen VL, Ganesh VS, Topcu M, Sebire G, Bodell A, Hill RS, Grant PE, Shugart YY, Imitola J, Khoury SJ, Guerrini R, Walsh CA. Mutations in ARFGEF2 implicate vesicle trafficking in neural progenitor proliferation and migration in the human cerebral cortex. Nat Genet. 2004 Jan;36(1):69-76.

Appointment Phone: (614) 293-4969
Fax: (614) 293-6111

Administrative Address:
395 W. 12th Ave., 7th Floor
Columbus, OH 43210